学历：博士

学科：遗传学

电子邮件：zhulei_evan@126.com

通讯地址：云南省昆明市西山区昆州路519号

简历：

朱磊，昆明医科大学附属第三医院（云南省肿瘤医院）助理研究员，博士毕业于中国科学院昆明动物研究所，于云南大学完成博士后研究工作，擅长多组学生信分析，长期专注肠道微生物组学及其在人类健康和疾病中的作用。以（共同）第一作者或（共同）通讯作者身份发表SCI论文十余篇，研究成果为理解肠道微生物与宿主健康的相互关系提供了见解。

经历：

2008/09-2012/07，黑龙江大学，生物工程专业，工学学士

2012/09-2015/07，华东师范大学，生物化学与分子生物学专业，理学硕士

2015/09-2021/07，中国科学院昆明动物研究所，遗传学专业，理学博士，

2021/08-2024/5， 云南大学，省部共建云南生物资源保护与利用国家重点实验室，博士后 

2024/8至今，昆明医科大学第三附属医院（云南省肿瘤医院），助理研究员

研究方向：

研究方向立足于肠道微生物整合生物学，旨在通过跨学科、多组学的整合研究，探究肠道微生物与宿主在协同进化过程中如何响应环境压力，并解析其调控宿主肿瘤发生、发展或抗性的微生态机制，最终为基于肠道微生物的肿瘤预防与表型定向干预策略提供坚实的理论依据和独特的微生物基因资源。

代表性成果和所获奖项：

1.Gao H, Zhuang D, Zhou H, Su Q, Hu X, Wang Y*, Bao W*, Zhu L*. A comprehensive analysis of human gut microbial biosynthesis gene clusters unveiling the dominant role of Paenibacillus. mSystems. 2025 Jul 22;10(7):e0061025. (IF=5.0, 中科院2区，末位通讯)

2.Zhu L*. ‘Am I redundant?’: how AI changed my career in bioinformatics. Nature. 2025 Oct 13. (IF=55.0, 中科院1区，唯一作者)

3.Wang X, Zhu L, Lan Y, et al. Convergent evolution of metabolic functions: Evidence from the gut microbiomes of humans and dogs[J]. iMetaOmics, e70059. 

4.Yin Qiuyuan, Zhu Lei*. Does co-localization analysis reinforce the results of Mendelian randomization?[J].Brain, 2024: awad295. (通讯作者, IF5-year = 14.6 )

5.Tian, Chen; Zhang, Tongzuo; Zhuang, Daohua; Luo, Yu; Li, Teng; Zhao, Fangfang; Sang, Jianan; Tang, Zecheng; Jiang, Peicheng; Zhang, Tao; Liu, Pengfei*; Zhu, Lei*; Zhang, Zhigang*; Industrialization drives the gut microbiome and resistome of the Chinese populations, mSystems, 2025, e01372(24) (共同通讯作者, IF5-year = 5.0)

6.Yue, Xiaojie#; Zhu, Lei#; Zhang, Zhigang ; Changes in RNA Splicing: A New Paradigm of Transcriptional Responses to Probiotic Action in the Mammalian Brain, Microorganisms, 2025, 13(1) (共同第一作者, IF5-year = 4.0)

7.Wang, Fengyang; Ruan, Wenpeng; Yin, Qiuyuan*; Zhu, Lei* ; Systematic druggable genome-wideMendelian randomization identifies therapeutic targets for hyperemesis gravidarum, Bmc Pregnancy and Childbirth, 2024, 24(1) (通讯作者, IF5-year = 2.8)

8.Yin Qiuyuan, Shi Guolin, Zhu Lei*. Association between gut microbiota and sensorineural hearing loss: a Mendelian randomization study[J]. Frontiers in Microbiology, 14: 1230125.  (通讯作者, IF5-year = 6.2 )

9.Shi Guolin, Wu Tingting, Li Xuetao, Zhao Debin, Yin Qiuyuan, Zhu Lei* (2024). Systematic genome-wide Mendelian randomization reveals the causal links between miRNAs and Parkinson’s disease. Frontiers in Neuroscience, 18, 1385675. (通讯作者, IF5-year = 5.2)

10.Wang Fengyang, Yin Qiuyuan, Zhu Lei*. Association between COVID‐19 and sensorineural hearing loss: Evidence from a Mendelian randomization study in European and East Asian population[J]. Immunity, Inflammation and Disease, 2023, 11(12): e1108. (通讯作者, IF5-year = 3.0)

11.Zhu Lei; Yin Qiuyuan; Irwin David M.; Zhang Shuyi; Phosphoenolpyruvate Carboxykinase 1 Gene (Pck1) Displays Parallel Evolution between Old World and New World Fruit Bats, PLos One, 2015, 10(3): 0-e0118666 (第一作者, IF5-year = 3.8)

12.Yin Qiuyuan; Zhu Lei; Liu Di; Irwin David M.; Zhang Shuyi; Pan Yi-Hsuan; Molecular Evolution of the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene Nrf2 in Old World Fruit Bats (Chiroptera: Pteropodidae), PLos One, 2016, 11(1): 0-e0146274 (共同一作, IF5-year = 3.8)

13.Meng Fanxing; Zhu Lei; Huang Wenjie; Irwin David M.; Zhang Shuyi; Bats: Body mass index, forearm mass index, blood glucose levels and SLC2A2 genes for diabetes, Scientific Reports, 2016, 6(1): 0-29960 (参与, IF5-year = 4.9)

14.Zhang Tao; Ren Haiqing; Du Zhihui; Zou Tong; Guang Xuefeng; Zhang Yanan; Tian Yuqing; Zhu Lei; Yu Jiangkun; Yu Xue; Zhang Zhigang; Dai Hailong. Diversified Shifts in the Cross Talk between Members of the Gut Microbiota and Development of Coronary Artery Diseases[J]. Microbiology Spectrum, 2022, 10(6): e02804-22. (参与, IF5-year = 5.9)

15.Tian C, Tang Z, Zhang X, Yao X, Li Y, Zhuang D, Luo Y, Li T, Bai L, Zhao F, Zhu L, Shi G, Jiang P, Gong Q, Zhou H, Gao H, Wu Q, Sang J, Liu X, Li X, Yu L, Zhang Z. Uncovering the gut microbiome and antibiotic resistome of mammals on the Tibetan Plateau. Sci China Life Sci. 2025 Sep 16. (参与，IF=9.5, 中科院1区)

16.Li X, Tian C, Zhuang D, Shi X, Tian L, Bai L, Gao H, Zhou H, Zhao F, Dai M, Zhu L, Yu J, Wu Q, Liu X, Zhang T, Sang J, Li T, Luo Y, Tang Z, Sahu SK, Xu X, Wang J, Liu H, Xiao L, Kristiansen K, Zhang Z. A unified catalog of 14,062 microbial species reference genomes provides new insight into the gut microbiota in high-altitude mammals. Microbiome. 2025 Nov 20;13(1):236 (参与，IF=12.7, 中科院1区)

承担课题：

2024年云南省教育厅科学研究基金教师类项目，基于蛋白质组与转录组数据整合分析挖掘肺癌治疗新靶点，4万，2025年3月—2027年2月

代表论著：无

主要学术兼职：无